When To Call During Home Infusion Red Flags You Should Not Ignore

February 5, 2026

Most home infusions go smoothly. But everyone feels safer when they know what is normal, what is not, and when it is time to call. This guide helps you recognize common red flags so you can act early and avoid bigger complications.


Quick Summary


If you are unsure whether something is normal, it is safer to call and ask. This guide lists common warning signs during home infusion, what to do next, and how to think through symptoms without panic.


Key Takeaways


  • Fever and chills should be taken seriously during home infusion.
  • Changes near the line site like redness, swelling, warmth, or drainage are a reason to call.
  • Allergic type symptoms should not be ignored.
  • “I am not sure” is a valid reason to contact your care team.


Why This Matters


Most patients are fine. The goal is not to make you anxious. The goal is to help you respond early if something changes. In home infusion, early action usually prevents bigger problems later.


A Simple Rule To Follow


If something feels sudden, unusual, or different from your normal routine, pause and call. You do not need to prove it is serious before asking for help.


Why this rule works


Many complications are easier to address when they are caught early. Waiting often makes things harder and more stressful.


Call Promptly If You Notice Any Of These Red Flags


Fever or chills


Fever and chills can be a sign that something needs clinical attention. Call promptly and follow the instructions given to you for your therapy.


Line site changes


Call if you notice: redness, swelling, warmth, drainage, or new pain near the catheter area.


Breathing or chest symptoms


Shortness of breath or chest discomfort should be treated seriously. Follow your care plan instructions. If symptoms are severe, seek emergency care.


Allergic type symptoms


Call if you notice rash, hives, itching, facial swelling, or a sudden reaction you have not experienced before.


Dizziness or fainting


New severe dizziness, fainting, or feeling unusually weak can be a reason to call quickly.


Tubing or equipment problems


Call if you notice leaking tubing, disconnected lines, broken caps, or anything that makes you unsure the setup is safe.


What To Do Next Without Overthinking


Step one pause


Stop what you are doing if you feel unsure. Do not push through.


Step two note the change


In one sentence write what you noticed and when it started. This helps your care team respond faster.


Step three call


Use your care team contact pathway and ask directly:
Is this expected for my therapy
What should I do next


Simple reminder


You do not need to have the perfect words. You just need to call.


Safety Note Disclaimer


This content is for education only and does not replace medical advice. If symptoms are severe or feel urgent, seek emergency care. Always follow your provider’s instructions for your specific therapy.


FAQs


What if I think I am overreacting


You are not. Call anyway. Early questions are safer than waiting.


What if symptoms come and go


If something repeats or feels unusual for you, call and describe the pattern. Even intermittent symptoms can matter.


What if a caregiver notices a change first


That is okay. Caregivers should report changes the same way and call early rather than waiting.


Related Reading


Central line care and infection prevention


https://www.pharmko.com/blog/central-line-care-home-infusion-infection-prevention


Caregiver training checklist


https://www.pharmko.com/blog/caregiver-training-checklist-home-infusion


If You Are Unsure About Next Steps Reach Out


https://www.pharmko.com/contact


References


CDC CLABSI resources

https://www.cdc.gov/hai/bsi/clabsi-resources.html

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